Research Fellow, Department of Radiology
Boston Children's Hospital | Harvard Medical School
WHEN: Thursday, June 6, 2019
TIME: 10:30 - 11:30 AM
WHERE: Room D215 - Abbotsford Campus
Rhodamines are fluorescent lipophilic cations that have high affinity for mitochondria and thus have been used extensively as potentiometric dyes for the study of these ‘powerhouses of the cell’ in vitro. Heart cells are rich in mitochondria, and thus our lab has developed radiolabeled rhodamine analogues that can be used to detect coronary heart disease in vivo using positron emission tomography (PET) molecular imaging techniques. After an introduction to PET and PET chemistry, he will discuss the radiochemical development and pre-clinical assessment of 18F-labelled rhodamine 6G (18F-Rho6G), which is currently undergoing first-in-human trials. He'll also discuss the role of 18F-Rho6G in the validation of autologous mitochondrial transplantation, a revolutionary treatment strategy that utilizes a patient’s own harvested mitochondria to preserve heart tissue that has been damaged by ischemia-reperfusion injury. Finally, in keeping with his commitment to expand the role of molecular imaging to address diseases associated with Indigenous and child populations, he’ll discuss his proposed strategy to leverage 18F-rhodamine technology towards the non-invasive detection of bacterial infections such as tuberculosis.
University of Calgary
Werklund School of Education
Exploring the journey towards ethno (mathematics) through Indigenous ways of knowing. Ethno (mathematics) makes space to reconnect the human with mathematics. This is a relationship that requires a reconnect after been lost or overlooked when imperialism and colonialism began to promote a mathematics that prioritized the abstract and focused on learning and truth as acquired through generalization and categorization. Kori is using story as a way to reignite lost connections between humans, the land, community, and mathematics. Her research brings together students with Elders and community to experience the depth of knowledge within stories of land and culture, creating more relatable and holistic connections to the math and science that surrounds us all.
Dr. Lee has devoted 35 years to fish cell line development and in her presentation, she recapped her past work and presented research projects for a fascinating future for fish invitromatics.
Invitromatics was a new term introduced in 2017 to describe a field of research that dates back 75 years but had no distinct terminology. Since the early 1940’s, scientists have been able to culture and grow cells outside an organism and maintain them for seemingly indefinite times as "cell lines". Most famous among the over 100,000 cell lines developed to date, is HeLa, the human cell line derived from a cervical cancer biopsy of an Afro-American woman in the early 1950’s. These cells were instrumental in the development of key vaccines and cancer medications, technologies for in vitro fertilization, gene mapping, cloning, among many other biotechnological applications. Although most cell lines available to date have been derived from humans, cell lines from many other organisms have been developed including fish.
As you celebrate 150 years of Confederation I hear the words of Chief Dan George spoken on Canada’s 100th birthday, “Today, when you celebrate your 100 years, oh Canada, I am sad for all the Indian people throughout the land.”
Chief Dan George finished with,“Oh God! Like the thunderbird of old I shall rise again out of the sea; I shall grab the instruments of the whiteman’s success-his education, his skills- and with these new tools I shall build my race into the proudest segment of your society”. Let us look at what has changed in the last 50 years.
Data Science Educator
DNA Learning Center
Cold Spring Harbor Laboratory
Joslynn Lee is Kiis’áanii [Pueblo of Laguna Parrot Clan] born for Tódik'ǫzhi [Navajo Salt Water Clan]. She received her BSc degree in chemistry and cellular & molecular biology from Fort Lewis College and a PhD in computational chemistry from Northeastern University. After completion of a postdoctoral fellowship at University of Minnesota Medical School, Duluth campus in the lab of Professor Matthew Slattery, she joined Cold Spring Harbor Laboratory’s DNA Learning Center in 2015 as Data Science Educator. She has served as co-author several publications in peer-reviewed scientific journals. Joslynn engages with Native American students and communities in the areas of chemistry and genomics.
Saskatchewan Disease Control Laboratory
Government of Saskatchewan
Leptospirosis is a disease caused by infection with strains of spirochaetes belonging to the genus Leptospira. Leptospires are found in fresh water and pathogenic strains are adapted to carriage in the renal tubules of host animals, from where they are excreted in urine, contaminating the environment. Leptospirosis is a globally widespread zoonosis, but is not often considered in the differential diagnosis of febrile illness in developed countries. Formerly considered to be an occupational disease, the major burden of disease is in tropical regions where diagnostic capacity is least developed. Recent large outbreaks associated with rainfall and changing human behavior have raised the public profile of this often overlooked zoonosis. This seminar will focus on the animal reservoirs of leptospirosis and the human activities that lead to infection.
UFV Adjunct Faculty, Biology
Former ballerina and Biologist with a twist, Canadian Carin Bondar has a PhD in biology from the University of British Columbia. She is the writer and host of the web series Wild Sex (Earth Touch Productions) that has garnered over 50 million views. Her TED talk on the same topic has reached an audience of over 2 million. The Nature of Sex, her book based on the series, is currently available in the UK, Australia and New Zealand, and will be available in the USA and Canada in 2016.